Targeting TL1A in IBD to Treat Both Inflammation and Fibrosis – A Wheel of Knowledge Challenge!

Overview

Provider Statement

This continuing education activity is provided by 

Support Statement

This activity is supported by an educational grant from Genentech, a member of the Roche Group.

Activity Description

Despite recent advances, many patients with inflammatory bowel disease (IBD) continue to experience persistent inflammation, fibrostenotic progression, and reduced quality of life, highlighting ongoing unmet needs in care. In this program, learners examine the scientific rationale for targeting TL1A, a key pathway involved in both inflammation and fibrosis. Expert faculty highlight the latest clinical evidence for TL1A inhibitors and discuss the potential for these novel agents to reshape IBD treatment paradigms and improve patient outcomes. Featuring expert-led discussion and an interactive, gamified Wheel of Knowledge Challenge, this program is designed to equip gastroenterologists with the latest developments in IBD therapy.

Target Audience

The intended audience for this activity is physicians and advanced practice providers in gastroenterology involved in the management of patients with IBD.

Learning Objectives

Upon successful completion of this activity, participants should be better able to:

• Recognize the limitations of current options for IBD management and the need for more effective, targeted therapies.
• Examine the rationale for targeting TL1A to reduce inflammation and fibrosis associated with IBD.
• Outline the clinical evidence of emerging TL1A therapies in IBD management.
• Evaluate the potential impact of TL1A therapies on IBD treatment paradigms and patient care.

Activity Chair

Jessica R. Allegretti, MD, MPH, FACG, AGAF
Medical Director, Infusion Services
Director, Crohn's and Colitis Center
Director of Clinical Research
Director, Fecal Microbiota Transplant Program
Division of Gastroenterology, Hepatology and Endoscopy
Brigham and Women's Hospital
Associate Professor of Medicine, Harvard Medical School
Boston, MA

Faculty

Adam S. Cheifetz, MD, AGAF, FACG
Director, Center for Inflammatory Bowel Disease
Medical Director, Infusion Services
Beth Israel Deaconess Medical Center
Professor of Medicine
Harvard Medical School
Boston, MA

Vipul Jairath, MBChB, DPhil, FRCPC
Professor of Medicine
Departments of Medicine, Epidemiology and Biostatistics
John and Susan McDonald Endowed Chair in IBD Clinical Research
Director, Advanced IBD Fellowship Program
Associate Chair (Research), Department of Medicine
Schulich School of Medicine & Dentistry
Western University
London, ON

Bruce E. Sands, MD, MS, AGAF, FACG
Chief, Dr. Henry D. Janowitz Division of Gastroenterology
Dr. Burrill B. Crohn Professor of Medicine
Icahn School of Medicine at Mount Sinai Hospital and Mount Sinai Health System
New York, NY

Planners/Reviewers

Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP
Linda A. Giarraputo, BS, PA-C

Accreditation

 In support of improving patient care, Vindico Medical Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Credit Designation

Vindico Medical Education designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Vindico Medical Education has been authorized by the American Academy of Physician Associates (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.25 AAPA Category 1 CME credits. Approval is valid until June 7, 2027. PAs should only claim credit commensurate with the extent of their participation.

Nurse practitioners can apply for AMA PRA Category 1 Credit(s)™ through the American Academy of Nurse Practitioners Certification Board (AANPCB). AANPCB will accept AMA PRA Category 1 Credit(s)™ from organizations accredited by ACCME.

This enduring material is approved for 1 year from the date of original release, June 8, 2026, to June 7, 2027.

How to Participate in This Activity and Obtain CE Credit

To participate in this activity, you must read the objectives, answer the polling and pretest questions, view the content, and complete the posttest and evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering 3 of the 4 posttest questions correctly. If a satisfactory score on the posttest is achieved, Vindico Medical Education will issue an AMA PRA Category 1 Credit(s)™ certificate or AAPA Category 1 CME certificate.

In addition to providing a downloadable certificate, CME Providers accredited by the Accreditation Council for Continuing Medical Education (ACCME) have the ability to transmit CME credit data for all US physicians to an online repository, the ACCME Program and Activity Reporting System (PARS). CME credit data submitted to PARS can be viewed, managed, and tracked by US physicians in "CME Passport," a free, centralized web application. US Physicians who opt-in by providing their medical license number, state of licensure, and date of birth will have their credits automatically reported to the ACCME.

Disclosures

Vindico Medical Education adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Individuals in a position to control the content of a continuing education activity, including faculty, planners, reviewers, or others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Relationship information is accurate at the time of content development.

Activity Chair and Faculty report the following relevant financial relationship(s)

Jessica R. Allegretti, MD, MPH, FACG, AGAF
Consultant: AbbVie, Genentech, Merck, Pfizer, Roivant, Shattuck Labs, Xencor
Speaker Contracted by Ineligible Company: AbbVie

Adam S. Cheifetz, MD, AGAF, FACG
Advisor: Prometheus
Consultant: AbbVie
Speaker Contracted by Ineligible Company: AbbVie

Vipul Jairath, MBChB, DPhil, FRCPC
Advisor: AbbVie, Boehringer Ingleheim, Merck, Pfizer, Prometheus, Roche/Genentech, Sanofi, Shattuck Labs, Spyre, Teva, Xencor
Consultant: AbbVie, Boehringer Ingleheim, Merck, Pfizer, Prometheus, Roche/Genentech, Sanofi, Shattuck Labs, Spyre, Teva, Spyre

Bruce E. Sands, MD, MS
Consultant: AbbVie, Merck, MSD, Pfizer, Sanofi, Spyre, Xencor
Speaker Contracted by Ineligible Company: AbbVie, Genentech, Merck, Pfizer

Planners/Reviewers report the following relevant financial relationship(s)

Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP
No relevant financial relationships to disclose.

Linda A. Giarraputo, BS, PA-C
No relevant financial relationships to disclose.

Vindico Medical Education staff report the following relevant financial relationship(s)

No relevant financial relationships to disclose.

Signed disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.

Unlabeled and Investigational Usage

The audience is advised that this continuing education activity may contain references to unlabeled uses of FDA-approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage. All activity participants will be informed if any speakers/authors intend to discuss either non–FDA-approved or investigational use of products/devices.

Accessibility

Vindico Medical Education is committed to providing an inclusive learning environment and ensuring equitable access to our educational content. Our educational activities may include accessibility features, such as captioning, transcripts, reading aloud, and other platform-supported tools, to assist learners.

Participants who require additional accommodation, alternative formats, or assistance accessing content are encouraged to contact us at CME@VindicoCME.com. Vindico will make all reasonable efforts to provide alternative formats in a timely manner.

Copyright Statement

Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680. Printed in the USA. Copyright © 2026 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. The material presented at or in any Vindico Medical Education continuing education activity does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the FDA. All readers and continuing education participants should verify all information before treating patients or utilizing any product.

Procedures for Reporting Copyright Infringement

If you suspect that any content in this activity violates your copyright, you can request the removal of such content or restrict access to it by contacting our designated copyright agent (as outlined below). In your email, kindly provide the following details:

• Specify the copyrighted work you believe has been infringed upon.
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Our agent for copyright issues relating to this web activity is as follows:
Vindico Medical Education, LLC
Attn: Faith Bantivoglio
6900 Grove Road, Building 300
Thorofare, NJ 08086
fbantivoglio@vindicocme.com
or call: 856-994-9400, ext. 614

CE Questions?

Contact us at cme@vindicoCME.com