IBD Advancements: The Promise of TL1A-Targeted Therapies

1.25CME

75MINS

Overview

Provider Statement

This continuing education activity is provided by Vindico Medical Education

Support Statement

This activity is supported by an educational grant from Genentech, a member of the Roche Group.

Activity Description

In recent years, a range of advanced therapies have been developed to address the underlying mechanisms of ulcerative colitis (UC) and Crohn’s disease (CD). Despite these agents targeting a variety of inflammatory pathways, roughly one-third of patients with inflammatory bowel disease (IBD) do not respond to currently available treatments, and approximately 40% lose response over time. Patients with chronic IBD often experience long-term complications, such as intestinal fibrosis. However, no effective antifibrotic agents have yet to be identified for this patient population. In Phase 2 and 3 clinical trials, TL1A inhibition has demonstrated promise for reducing both intestinal inflammation and fibrosis. In this CE activity, experts in the field address unmet needs in IBD care, examine the role of the TL1A pathway in IBD, report the latest clinical evidence on emerging TL1A inhibitors, and discuss how TL1A may shift treatment paradigms for UC and CD.

Target Audience

The intended audience for this activity is gastroenterologists involved in the management of patients with IBD.

Learning Objectives

Upon successful completion of this activity, participants should be better able to:

Describe the limitations and unmet needs associated with current treatment options for the management of patients with IBD.
Examine the role of the TL1A pathway in the pathogenesis of IBD and its potential as a therapeutic target.
Outline the latest clinical evidence of emerging TL1A-targeted therapies from both an anti-inflammatory and antifibrotic perspective.
Review how emerging TL1A inhibitors may impact existing treatment paradigms.

Activity Chair

Silvio Danese, MD, PhD
Director, Gastroenterology and Endoscopy
IRCCS Ospedale San Raffaele
Professor of Gastroenterology
University Vita-Salute San Raffaele
Milan, Italy

Faculty

Jessica R. Allegretti, MD, MPH, FACG, AGAF
Medical Director, Infusion Services
Director, Crohn's and Colitis Center
Director of Clinical Research
Director, Fecal Microbiota Transplant Program
Division of Gastroenterology, Hepatology and Endoscopy
Brigham and Women's Hospital
Associate Professor of Medicine, Harvard Medical School
Boston, MA

Marla C. Dubinsky, MD
Professor of Pediatrics and Medicine
Chief, Division of Pediatric Gastroenterology and Nutrition
Co-Director, Susan and Leonard Feinstein IBD Clinical Center
Co-Director, Marie and Barry Lipman IBD Preconception and Pregnancy Planning (I-PrePP) Clinic
Mount Sinai Kravis Children’s Hospital
Icahn School of Medicine at Mount Sinai
New York, NY

Planner/Reviewer

Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP

Accreditation

ACCME Jointly accredited In support of improving patient care, Vindico Medical Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Credit Designation

Vindico Medical Education designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This enduring material is approved for 1 year from the date of original release, December 1, 2025, to November 30, 2026.

How to Participate in This Activity and Obtain CE Credit

To participate in this activity, you must read the objectives, answer the polling and pretest questions, view the content, and complete the posttest and evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering 75% of the posttest questions correctly. If a satisfactory score on the posttest is achieved, Vindico Medical Education will issue an AMA PRA Category 1 Credit(s)™ certificate.

In addition to providing a downloadable certificate, CME Providers accredited by the Accreditation Council for Continuing Medical Education (ACCME) have the ability to transmit CME credit data for all US physicians to an online repository, the ACCME Program and Activity Reporting System (PARS). CME credit data submitted to PARS can be viewed, managed, and tracked by US physicians in "CME Passport," a free, centralized web application. US Physicians who opt-in by providing their medical license number, state of licensure, and date of birth will have their credits automatically reported to the ACCME.

Disclosures

Vindico Medical Education adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Individuals in a position to control the content of a continuing education activity, including faculty, planners, reviewers, or others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Relationship information is accurate at the time of content development.

Activity Chair and Faculty report the following relevant financial relationship(s)

Jessica R. Allegretti, MD, MPH, FACG, AGAF
Consultant: AbbVie, BMS, Celltrion, Genentech, Ferring, GSK, Janssen, Merck, Pfizer, Roivant, Seres, Shattuck Labs, TRXbio, Vedanta, Xencor
Speaker Contracted by Ineligible Company: AbbVie, Janssen
Independent Research Contractor: AbbVie

Silvio Danese, MD, PhD
No relevant financial relationships to disclose.

Marla C. Dubinsky, MD
Consultant: AbbVie, Abivax, BMS, Celltrion, Genentech, Johnson & Johnson, Merck, Pfizer, Sanofi, Spyre, Takeda
Speaker Contracted by Ineligible Company: AbbVie, Abivax, AstraZeneca, BMS, Celltrion, Genentech, Janssen, Merck, Pfizer, Prometheus, Sanofi, Spyre, Takeda

Planner/Reviewer reports the following relevant financial relationship(s)

Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP
No relevant financial relationships to disclose.

Vindico Medical Education staff report the following relevant financial relationship(s)

No relevant financial relationships to disclose.

Signed disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.

Unlabeled and Investigational Usage

The audience is advised that this continuing education activity may contain references to unlabeled uses of FDA-approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage. All activity participants will be informed if any speakers/authors intend to discuss either non–FDA-approved or investigational use of products/devices.

Copyright Statement

Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680. Printed in the USA. Copyright © 2025 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. The material presented at or in any Vindico Medical Education continuing education activity does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the FDA. All readers and continuing education participants should verify all information before treating patients or utilizing any product.

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