Multiple sclerosis (MS) is a chronic, immune-mediated inflammatory disease of the central nervous system that affects more than 2.3 million people worldwide. Over the past several years, the scientific advances in the pathophysiology and therapeutic options of MS have undergone tremendous expansion. It is critical for health care providers to be up-to-date with the most recent developments in the understanding of this disease, as well as its diagnosis and treatment approaches. In this CME program, leading experts will review various aspects of MS, including the advancements in imaging and biomarkers to diagnose the disease and monitor its progression. In addition, new therapeutic targets, symptomatic management, treatment during pregnancy, as well as the mechanisms of action, safety, and efficacy of established and emerging therapies, will also be discussed.